Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium

LS van Velzen; L Colic; Z Ceja; MR Dauvermann; LM Villa; HS Savage; YJ Toenders; N Dehestani; AH Zhu; AI Campos; LE Salminen; M Alda; I Agartz; N Alexander; R Ayesa-Arriola; ED Ballard; N Banaj; C Barkhau; Z Başgöze; J Bauer; F Benedetti; K Berger; B Besteher; K Brosch; M Canal-Rivero; S Cervenka; R Colle; CG Connolly; E Corruble; P Courtet; B Couvy-Duchesne; B Crespo-Facorro; KR Cullen; U Dannlowski; J Deverdun; AM Diaz-Zuluaga; LMF Dietze; JW Evans; N Fani; K Flinkenflügel; NP Friedman; IH Gotlib; NA Groenewold; D Grotegerd; T Hajek; AS Hatoum; M Hermesdorf; IB Hickie; Y Hirano; TC Ho; Y Ikemizu; F Iorfino; JC Ipser; Y Isobe; AP Jackowski; F Jollant; T Kircher; M Klug; SM Koopowitz; A Kraus; A Krug; E Le Bars; EJ Leehr; M Li; ETC Lippard; C Lopez-Jaramillo; II Maximov; AM McIntosh; KA McLaughlin; SR McWhinney; S Meinert; E Melloni; PB Mitchell; B Mwangi; I Nenadić; S Nerland; E Olie; V Ortiz-García de la Foz; PM Pan; F Pereira; F Piras; F Piras; S Poletti; AE Reineberg; G Roberts; R Romero-García; MD Sacchet; GA Salum; AL Sandu; CM Sellgren; E Shimizu; HR Smolker; JC Soares; JD Steele; F Stein; DJ Stein; B Straube; L Teutenberg; F Thomas-Odenthal; P Usemann

Journal article

Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium

LS van Velzen, L Colic, Z Ceja, MR Dauvermann, LM Villa, HS Savage, YJ Toenders, N Dehestani, AH Zhu, AI Campos, LE Salminen, M Alda, I Agartz, N Alexander, R Ayesa-Arriola, ED Ballard, N Banaj, C Barkhau, Z Başgöze, J Bauer Show all

Translational Psychiatry | Published : 2025

DOI: 10.1038/s41398-025-03602-1

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Abstract

Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity and radial diffusivity) for 24 WM tracts and one global measure were pooled across 40 cohorts. We compared these measures among individuals with a ps..

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